ficus deltoidea in malay

The plant produces figs that are spherical to round, with a width of 1.0 to 1.5 cm and coloured yellow to orange-red (Figure 1). Ficus. [11] evaluated the potential of five extracts and three fractions of F. deltoidea in order to enhance basal and insulin-stimulated glucose uptake into the Chang liver cell line. The synonym is F. deltoidea var. This was further supported by Samah et al. It is an evergreen shrub, raising about two metres tall with grey bark and spoon-shaped leaves. A study by Uyub et al. Oh MJ, Abdul Hamid M, Ngadiran S, Seo YK, Sarmidi MR, Park CS. The ePub format uses eBook readers, which have several "ease of reading" features Ficus deltoidea Jack (Moraceae) has had a long history of use in traditional medicine among the Malays to alleviate and heal ailments such as sores, wounds, and rheumatism and as an after-birth tonic and an antidiabetic drug. trengganuensis Corner [8]. A genotoxicity study was performed using the Ames test with the TA98 and TA100 Salmonella typhimurium strains and showed the F. deltoidea extract did not have any potential to induce mutations in the presence or absence of S9 metabolic activation [36]. Mohd Lip J, Nazrul Hisham D, Arif Zaidi J, et al. The negative control rats showed very severe gastric mucosal damage as well as edema and leucocyte permeation of the submucosal layer, suggesting that F. deltoidea extract protects against ulcers, demonstrated by the reduction in ulcer areas, inhibition of submucosal edema, and reduced leucocyte infiltration. Chemical constituents identified in F. deltoidea. It is widely distributed throughout Peninsular Malaysia, Thailand, Sumatra, Java, Borneo and Moluccas ( Berg and Corner, 2005 ). Ong et al. Evidence-based Complementary and Alternative Medicine : eCAM. Generating an ePub file may take a long time, please be patient. 1Institute of Systems Biology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, 2Biotechnology Research Centre, Malaysian Agricultural Research and Development Institute, P.O. [6] isolated and identified moretenol from F. deltoidea leaves using nuclear magnetic resonance (NMR) and mass spectrometers. This review will unify fragmented information regarding F. deltoidea in terms of its botany, traditional uses, phytochemistry, and pharmaceutical effects in order to facilitate better understanding and provide further support for the ethnopharmacological use of this important species. Lifespan: The patients were given F. deltoidea 350 mg orally twice daily for two months. Aqueous and ethanol extracts of F. deltoidea were found to have anticancer activity against human ovarian carcinoma cell line A2780 using a cell-based assay and confirmed by microscopic observation [30]. Ficus deltoidea not only has been used as a medicine for various ailments in the Malay Archipelago, but also has been distributed and formulated as capsules, tea, and tonic tea throughout Malaysia. lutescens (Desf.) This was further supported by Samah et al. Furthermore, following UVB irradiation enhanced MMP-1 expression that would usually be observed decreased after treatment with the F. deltoidea extract in a dose-dependent manner. Ficus deltoidea was also reported to have antimelanogenic effects in reducing melanogenesis biosynthesis for melanin production [22]. This study, therefore, investigated the effects of a standardized ethanolic-water extract of Ficus deltoidea Angustifolia (FD-A) on blood pressure (BP) in spontaneously hypertensive rats (SHR). Lip}, journal={Planta Medica}, year={2007}, volume={73} } Characterization antibacterial constituent from Ficus deltoideus Jack … borneensis Corner, F. deltoidea forma subhirsuta Corner, F. deltoidea var. Box 12301, 50774 Kuala Lumpur, Malaysia, Evidence-Based Complementary and Alternative Medicine, Apigenin-6-C-arabinosyl-8-C-glucoside (isoschaftoside), Apigenin-6-C-glucoside-8-C-arabinoside (schaftoside), L. Grison-Pigé, M. Hossaert-McKey, J. M. Greeff, and J. M. Bessière, “Fig volatile compounds—a first comparative study,”, L. Grison-Pigé, J. M. Bessière, and M. Hossaert-McKey, “Specific attraction of fig-pollinating wasps: role of volatile compounds released by tropical figs,”, M. H. Omar, W. Mullen, and A. Crozier, “Identification of proanthocyanidin dimers and trimers, flavone C-glycosides, and antioxidants in, C. Y. Choo, N. Y. Sulong, F. Man, and T. W. Wong, “Vitexin and isovitexin from the leaves of, J. Mohd Lip, D. Nazrul Hisham, J. Arif Zaidi et al., “Isolation and identification of moretenol from, S. Suryati, H. Nurdin, D. Dachriyanus, and M. Hj Lajis, “Structure elucidation of antibacterial compound from, S. L. Ong, A. P. K. Ling, R. Poospooragi, and S. Moosa, “Production of Flavonoid compounds in cell cultures of, C. C. Berg, “Flora Malesiana precursor for the treatment of Moraceae 3: Ficus subgenus Ficus,”, I. H. Burkill and M. Haniff, “Malay village medicine,”, Z. Adam, M. Hamid, A. Ismail, and S. Khamis, “Effect of, Z. Adam, S. Khamis, A. Ismail, and M. Hamid, “Inhibitory properties of, E. Farsi, A. Shafaei, S. Y. Hor et al., “Correlation between enzymes inhibitory effects and antioxidant activities of standardized fractions of methanolic extract obtained from, Z. Adam, A. Ismail, S. Khamis, M. H. Mohd. … This summary could be beneficial for future research aiming to exploit the therapeutic potential of this useful, medicinal species. 2010). Institute of Systems Biology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, Biotechnology Research Centre, Malaysian Agricultural Research and Development Institute, P.O. The leaves possess anti-inflammatory effects against various inflammatory responses as well as pain-associated inflammatory responses. Life form: Bush: Family: Moraceae: Origin: Malaysia, Indonesia, Southern Philippines: Ease of cultivation: Easy enough for growing a plant: The size: In room conditions, most often up to 90 cm. [21] in order to verify using this plant to reduce sensitivity to painful stimuli using chemical and thermal nociception models. Ficus deltoidea not only has been used as a medicine for various ailments in the Malay Archipelago, but also has been distributed and formulated as capsules, tea, and tonic tea throughout Malaysia. Ficus deltoidea not only has been used as a medicine for various ailments in the Malay Archipelago, but also has been distributed and formulated as capsules, tea, and tonic tea throughout Malaysia. Adam et al. We are experimenting with display styles that make it easier to read articles in PMC. [35] confirmed that F. deltoidea leaves do not contain toxic elements by evaluating toxicological elements (lead, cadmium, arsenic, and mercury) using atomic absorption spectroscopy technique, standardisation parameters (moisture, volatile, total ash, and acid insoluble ash), and Microbial Limit Test (MLT) for microbial contamination. recurvata Kochummen, and F. deltoidea var. Later on, an antibacterial compound known as lupeol (C30H50O) was also isolated from the leaves of F. deltoidea and exhibited toxicity against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli [7]. It is distributed throughout the region known as Malesia, which includes Thailand, Indonesia, and Malaysia [9]. (a) Vitexin and (b) isovitexin chemical structures. [4, 5]. Hamidun Bunawan, Noriha Mat Amin, Siti Noraini Bunawan, Syarul Nataqain Baharum, Normah Mohd Noor, "Ficus deltoidea Jack: A Review on Its Phytochemical and Pharmacological Importance", Evidence-Based Complementary and Alternative Medicine, vol. borneensis Corner, F. deltoidea forma subhirsuta Corner, F. deltoidea var. In the subchronic study, there were no significant adverse effects on body weight, organ weight, food consumption, mortality, haematology, histopathology, and clinical chemistry, except an increase in the serum urea level [36]. This might be due to different types of phytochemical property in those two extracts. motleyana and var. intermedia , var. oligoneura (Miq.) The metabolites identified from F. deltoidea to date are presented in Table 1. @article{Musa2007MasC, title={Mas cotek (Ficus deltoidea): A new potential medicinal plant in Malaysia}, author={Y. Musa and J. Ficus deltoidea is an evergreen shrub that reaches a height of 2 meters, with whitish grey bark, leaves broadly spoon-shaped to obovate, with a leaf length between 4 cm and 8 cm, coloured bright green above, and rust-red to olive-brown beneath. Draman S, Aris MAM, Razman A, et al. Methanol extracts of F. deltoidea showed highest activity against H. pylori with an inhibition zone diameter of 12.0 ± 0.6 mm followed by petroleum ether 10.0 ± 0.6 mm and chloroform extract 8.0 ± 0.1 mm. The authors expressed their thanks to Kathryn Ford and Lukas Dusik for their editorial comments on the paper. Z. Hashim, “Phytochemical screening for antibacterial activity of potential Malaysian medicinal plants,”, O. Hasham R, Choi HK, Sarmidi MR, Park CS. [21] in order to verify using this plant to reduce sensitivity to painful stimuli using chemical and thermal nociception models. Jamal P, Karim IA, Abdullah E, Raus RA, Hashim YZ. [35] confirmed that F. deltoidea leaves do not contain toxic elements by evaluating toxicological elements (lead, cadmium, arsenic, and mercury) using atomic absorption spectroscopy technique, standardisation parameters (moisture, volatile, total ash, and acid insoluble ash), and Microbial Limit Test (MLT) for microbial contamination. [26]. A further study on the effects of F. deltoidea methanolic extract on the reproductive systems of male rats was conducted by Norrizah et al. Further study on the acute toxicity showed that the LD50 of the extract was greater than 5000 mg/kg on Sprague Dawley rats treated with five different doses of the extract. Ficus deltoidea has more than 80 subspecies in Malaysia!!! The results demonstrated that extracts of leaves of F. deltoidea have significant anti-inflammatory properties, suggesting that the extracts may be useful for relieving pain by reducing inflammation. Predictably, gastric protection was more effective with use of 500 mg kg−1   Microphthalmia-associated transcription factor (MITF) expression also decreased when F. deltoidea extract was applied, suggesting that F. deltoidea has strong potential for use as a depigmenting agent in cosmetics. There are many varians of Ficus deltoidea but only two varians are widely used which are Ficus deltoidea var. Surprisingly, the study found that the leaf extract decreased testes and epididymis weight, sperm count, and sperm viability. angustifolia (Miq.) These may help to strengthen our understanding of this highly therapeutic plant for commercial exploitation. Predictably, gastric protection was more effective with use of 500 mg kg−1   F. deltoidea extract compared to 250 mg kg−1. Additionally, F. deltoidea fruits are traditionally chewed to relieve toothache, cold, and headache and the entire Ficus deltoidea plant is also traditionally used as an aphrodisiac tonic and as health tonic by women in Indonesia. Ficus deltoidea Jack (Moraceae) has had a long history of use in traditional medicine among the Malays to alleviate and heal ailments such as sores, wounds, and rheumatism and as an after-birth tonic and an antidiabetic drug. deltoidea Jack (FD) is a well-known plant used in Malay folklore medicine to lower blood glucose in diabetic patients. 2014, Article ID 902734, 8 pages, 2014. https://doi.org/10.1155/2014/902734, 1Institute of Systems Biology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia, 2Biotechnology Research Centre, Malaysian Agricultural Research and Development Institute, P.O. angustifolia, var. Methanol extracts of F. deltoidea showed highest activity against H. pylori with an inhibition zone diameter of  mm followed by petroleum ether  mm and chloroform extract  mm. [12] reported that hot aqueous, ethanolic, and methanolic extracts of F. deltoidea inhibit rat intestine α-glucosidase activity significantly, an enzyme that is accountable for carbohydrate digestion to condense the effect of carbohydrate in blood sugar. Malays in the Peninsular Malaysia have been using the powdered root and leaves of F. deltoidea to treat wounds, rheumatism, sores, and other ailments for centuries. Effect of, Norrizah JS, Norizan A, Sharipah Ruzaina SA, Dzulsuhaimi D, Nurul Hidayah MS. Cytotoxicity activity and reproductive profiles of male rats treated with methanolic extracts of, Shafaei A, Farsi E, Khadeer Ahamed BM, et al. A genotoxicity study was performed using the Ames test with the TA98 and TA100 Salmonella typhimurium strains and showed the F. deltoidea extract did not have any potential to induce mutations in the presence or absence of S9 metabolic activation [36]. Deltoidea (FDD) and F. deltoidea var. These invaluable products are explored for the potential discovery of novel biomolecules that have possible future uses. kunstleri, var. Samsulrizal et al. Phytochemical screening for antibacterial activity of potential Malaysian medicinal plants. Ficus deltoidea is used in Malay traditional medicine for the treatment of a number of disorders, including hypertension. Both of the plant extracts have different effects on cell growth: the aqueous extract promoted cell detachment, while the ethanolic extract decreased cell proliferation. Four groups of rats were used in the experiment: negative controls (treated with distilled water), 250 and 500 mg kg−1 of F. deltoidea extract, and positive controls (treated with omeprazole). Pretreatment with F. deltoidea extract demonstrated considerably less gastric mucosal lesions produced by ulcerogens compared to the negative control. Flora Malesiana precursor for the treatment of Moraceae 3: Ficus subgenus Ficus. [14] to evaluate the ethanolic effect of F. deltoidea on glucose levels in normal rats showed that all doses reduced fasting blood glucose, especially after 6 hours of administration. The principle bioactive metabolites have to be examined for their bioactivities and their mechanism of action needs to be determined, in conjunction with analysing the pharmacokinetics and physiological pathways of specific compounds in F. deltoidea. F. deltoidea extract compared to 250 mg kg−1. oligoneura (Miq.) This plant is native to the Malayan Archipelago and has been introduced elsewhere. trengganuensis Corner [1]. Adam et al. Furthermore, following UVB irradiation enhanced MMP-1 expression that would usually be observed decreased after treatment with the F. deltoidea extract in a dose-dependent manner. A. Zakaria, M. K. Hussain, A. S. Mohamad, F. C. Abdullah, and M. R. Sulaiman, “Anti-inflammatory activity of the aqueous extract of, Z. Abdullah, K. Hussain, I. Zhari, and M. A. Rasadah, “Anti-inflammatory activity of standardised extracts of leaves of three varieties of, M. R. Sulaiman, M. K. Hussain, Z. Modern pharmacological studies demonstrated that this plant has a wide variety of beneficial attributes for human health. A different study conducted by Adam et al. Ficus deltoidea was also reported to have antimelanogenic effects in reducing melanogenesis biosynthesis for melanin production [22]. peltata Corner, F. deltoidea var. Both of the plant extracts have different effects on cell growth: the aqueous extract promoted cell detachment, while the ethanolic extract decreased cell proliferation. Interestingly, rats given aqueous and ethanolic leaf extracts of F. deltoidea demonstrated significantly increased testosterone levels, sperm count, and motility and showed a reduction in the blood clotting levels and blood glucose level, as well as a reduction in sperm abnormalities. The effect of F. deltoidea on LDH-C4 activity was also seen positive for maintaining healthy sperm. The ePub format is best viewed in the iBooks reader. Additionally, F. deltoidea fruits are traditionally chewed to relieve toothache, cold, and headache and the entire Ficus deltoidea plant is also traditionally used as an aphrodisiac tonic and as health tonic by women in Indonesia. Find Scientific Name Ficus Deltoidea Malay Name stock images in HD and millions of other royalty-free stock photos, illustrations and vectors in the Shutterstock collection. It was found that flavan-3-ol monomers and proanthocyanidins contributed 85% of the antioxidant activity of the aqueous extract of F. deltoidea (Figure 3). Currently, two bioactive constituents known as vitexin and isovitexin have been isolated, identified, and evaluated to show α-glucosidase inhibition [10]. The group that was treated with a placebo containing 5% and 10% of F. deltoidea extracts showed significantly accelerated wound healing in comparison with deionized water (negative control) and blank placebo treatments. Ficus deltoidea extract activity was investigated using cultured B16F1 melanoma cells focusing on the characterization of tyrosinase, the enzyme that is required for melanin production. For many years there has been a tremendous interest in biological products gained from megadiversity countries like Malaysia. Ficus deltoidea is a native and widely distributed throughout Malaysia, Thailand, Sumatra, Java, Kalimantan, Sulawesi and Moluccas . Isolation and identification of moretenol from, Suryati S, Nurdin H, Dachriyanus D, Hj Lajis M. Structure elucidation of antibacterial compound from, Ong SL, Ling APK, Poospooragi R, Moosa S. Production of Flavonoid compounds in cell cultures of, Omar MH, Mullen W, Crozier A. Treatment with F. deltoidea extract also significantly inhibited UV-induced TNF-α, IL-1α, IL-6, and COX-2 expression [23]. Ficus deltoidea is one of the well-known herbs in Malay traditional medicine. deltoidea, var. Ficus deltoidea Jack is a shrub or small tree that belongs to the fig family (Moraceae). F. deltoidea from Moraceae family which also known as “mas cotek”, “serapat angin” and “telinga beruk” in Malaysia, “tabat barito” in The synonym is F. deltoidea var. Corner [1]. bilobata , var . The scientific research on F. deltoidea indicated that this plant has received increasing interest in recent years. Another study by Farsi et al. Ficus deltoidea Jack or known as Mas Cotek in Malaysia is one of the most promising medicinal plants to be commercialised due to its high antioxidant activities. Previously, Hakiman and Maziah [24] described another experiment where different aqueous extracts of F. deltoidea accessions were evaluated for their antioxidant activities using several assays such as FRAP, free radical scavenging assay, total polyphenol, flavonoid, phenolic acid, and vitamin C. 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Evidence on its leaves, Sarmidi MR, Park CS, natural plant products have been isolated identified! Omar et al, Hossaert-McKey M, Zarin a augment labour and hastening parturition Antidiabetic and properties... The reproductive systems of male rats was conducted by Norrizah et al could be beneficial future! From megadiversity countries like Malaysia and therapeutic cholesterol control treatment 2013 Dec 19 ; accepted Feb. Future research aiming to exploit the therapeutic potential of this highly therapeutic plant for commercial exploitation subspecies in Malaysia regulating!

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